Leishmania amazonensis Infection in Nude Mice.
نویسندگان
چکیده
منابع مشابه
Low and high-dose intradermal infection with Leishmania major and Leishmania amazonensis in C57BL/6 mice.
A model of skin infection with Leishmania amazonensis with low doses of parasites is compared to infection with high doses of L. amazonensis and low and high doses of Leishmania major. C57BL/6 mice were infected with 10³ or 10(6) parasites in the ear and the outcome of infection was assessed. The appearance of lesions in mice infected with 10³ parasites was delayed compared to mice infected wit...
متن کاملHairless mice as an experimental model of infection with Leishmania (Leishmania) amazonensis.
HRS/J Hairless mice have been investigated as an experimental model in cutaneous leishmaniasis induced by Leishmania (Leishmania) amazonensis. The animals were inoculated with 10(6) promastigotes into the right hind footpad and the course of infection was followed up for 30, 60 and 90 days. BALB/c mice were infected and used as control. Hairless mice were susceptible to L. (L.) amazonensis infe...
متن کاملProtection of C3HeB/FeJ mice against Leishmania amazonensis challenge after previous Leishmania major infection.
The Th1 response elicited in mice infected with Leishmania major has been used as a model to characterize cellular immune defects associated with L. amazonensis infection. However, it is not known if the immune response associated with the infection by virulent L. major parasites can promote resistance to a subsequent L. amazonensis infection. Our data demonstrate that C3HeB/FeJ mice infected s...
متن کاملLeishmania amazonensis
Resistance to and recovery from leishmania infection is dependent on cell-mediated immunity. C57BL/6 mice are resistant to Leishmania amazonensis (La) infection but susceptible to LP-BM5 murine leukemia virus (MuLV) infection. MuLVinfection leads to a state ofimmunodeficiency characterized by severe compromise ofcell-mediated immunity. When infected with La alone, C57BL/6 mice developed a smaU ...
متن کاملCXCL10/gamma interferon-inducible protein 10-mediated protection against Leishmania amazonensis infection in mice.
Leishmania amazonensis can cause progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of proinflammatory cytokines and chemokines and in activation of antigen-specific CD4(+) T cells. These impairments are independent of interleukin-4 (IL-4) but partially due to IL-10 production. The precis...
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ژورنال
عنوان ژورنال: Experimental Animals
سال: 1999
ISSN: 1341-1357,1881-7122
DOI: 10.1538/expanim.48.119